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Tutor profile: Sarah J.

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Sarah J.
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Questions

Subject: MCAT

TutorMe
Question:

what is the best experimental demonstration to analyze the effects of FMR11 gene deletion on the rate of histone acetylation? Comparing histone acetylation in wild-type and FMR11 cells by?

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Sarah J.
Answer:

Western Blot. an easy way to remember the methods of biochemical analyses is SNoW DRoP or S. D N R o. o W P (S)southern blot = (D)NA (N)orthern blot = (R)NA o-o (W)estern blot = (P)rotein

Subject: Medicine

TutorMe
Question:

72 year old man develops mild abdominal pain and bloody diarrhea after undergoing urgent cholecystectomy. surgery was complicated by an episode of hypotension that was treated with a bolus oof IV crystalloid fluids. patient had no previous gastrointestinal bleeding. his last colonoscopy 10 years ago was normal. past medical history is notable for hypertension, hyperlipidemia, type 2 DM, and a myocardial infarction 7 years ago. patient smoked for 40 years and quit after the Myocardial infarction. colonoscopy would show pathology in what portions of the large bowel.

Inactive
Sarah J.
Answer:

patient has acute nonexclusive ischemic colitis. Non occlusive ischemia may occur at the margins of the anastomotic distributions. The "watershed" areas are primarily in the left colon at the splenic flexure (border between SMA and IMA supply) and rectosigmoid junction (border between the sigmoid artery and superior rectal artery). answer: rectosigmoid junction

Subject: Biochemistry

TutorMe
Question:

A scientist is developing an agent that is specifically blocking the interaction of inositol triphosphate with its intracellular receptor. the study is then performed in which vascular smooth muscle cells are divided into 2 groups: an experimental group treated with the receptor blocker and an untreated group. both groups are exposed to phenylephrine. compared to the control cells, decreased activity of what enzymes is most likely observed in the experimental cells?

Inactive
Sarah J.
Answer:

After a ligand binds to a G protein-coupled receptor that activates phospholipase C, membrane phospholipids are broken down into diaylglycerol (DAG) and inositol triphosphate (IP3). Protein Kinase C is subsequently activated by DAG and calcium; the latter is released from the endoplasmic retuculum under the influence of IP3. When phenylephrine binds to an alpha 1 receptor on vascular smooth muscle cells, the alpha subunit of Gs activates phospholipase C --> IP3 and DAG --> Dag stimulates protein Kinase C --> phosphorylates downstream intracellular proteins to produce is physiologic effects (smooth muscle contraction). IP3 produces most its effects by increasing intracellular calcium, which also activates protein kinase C. --Therefore answer = Protein Kinase C activity would be reduced in the experimental group compared to the control group as calcium release from the ER is interrupted.

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