Tutor profile: Aabra M.
Subject: Organic Chemistry
What makes an epoxide susceptible to nucleophile attacks?
An epoxide is a three-membered ring with one oxygen connected to two carbons in a ring. The angle strain from the overlap of orbitals in the cyclic compound and electron pull of the oxygen from the carbons, makes the molecule more susceptible to attacks from electron-rich nucleophiles on the carbons.
How does Gibbs Free Energy allow for a reaction to be spontaneous?
Essentially, Gibbs Free Energy provides a potential for a reaction to in the reverse direction. The more negative the Gibbs Free Energy the less likely the reaction will be to go in the reverse direction. Similarly, if the Gibbs Free Energy is positive, the reaction will most likely go in the reverse direction. Thus, if a reaction has negative Gibbs Free Energy, the reaction will proceed in the forward direction, making it spontaneous.
How does activity of telomerase differ in cancerous cells in comparison to non-cancerous cells?
Telomerase activity is highly regulated in non-cancerous cells and is controlled to assure that it does not prevent telomere shortening. Whereas, in cancerous cells, telomerase plays an active role in maintaining the telomere length, and prevents the telomeres from shortening. Thus, assuring the survival of cancerous cells.
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