Tutor profile: Ryan L.

"How does one right a question on the subject of writing?" Find the misused word

The word "right" is misused here. It is a homophone for "write", they sound the same but have different meanings

The genome editing technology CRISPR has become widely used for its application in disease relevance. Although first recognized for creating genetic knock-outs, this technology has been adapted to also create genetic knock-ins. Consider how both of these types of technologies could apply to treating a disease of your choice (hint: use Sickle Cell Anemia if you can't think of anything.)

As many human diseases are a result of genetic mutations and subsequent translation of mutant protein, there are tons of answers to this question. In the case of Sickle cell anemia, there are currently clinical trials aimed at treating using both knock-ins and knock-outs. Whereas, if you knock-out a gene suppressing fetal hemoglobin you can alleviate symptoms, or on the contrary, knocking-in a repaired beta-globin gene to replace the mutated version.

What is the key functional difference between DNA and RNA as it pertains to their role in transcription?

The main function of DNA is to store and replicate genetic information, evidenced by its increased stability over RNA. In fact, mutations in DNA can be very detrimental to an organism. Therefore, DNA acts as a template strand. From this template strand, RNA is synthesized (mRNA to be exact), and this RNA is later exported from the nucleus to undergo transcription. Put simply, DNA is the template and RNA is the copy.