Tutor profile: Keith H.
A 70-year-old patient is being treated with a fungal infection and also takes tamsulosin (Flomax). The team wants to start him on posaconazole (Noxafil). What would recommend the team should do?
Here there is an interaction of CYP3A4 between the tamsulosin and posaconazole. Posaconazole is a strong inhibitor of CYP3A4 and would lead to a higher level of tamsulosin. This would increase the risk of a hypotensive episode (which could lead to a fall, especially given the patient's age). We should recommend switching to another antifungal agent that would cover the fungal infection.
What is a redox reaction and how do you identify it?
A redox reaction is when an atom gains or loses electrons during a reaction, leaving it with a different charge than before. LEO the lion says GER. Lose electrons (becomes more positive) oxidation| Gain electrons (become more negative) reduction. You would have to assign oxidation states to each atom in the reaction to determine if a charge has changed.
What is the difference between translation and transcription within the scope of the central dogma of protein synthesis?
Transcription is the process of the cell creating mRNA from DNA to be used to make proteins while allowing the DNA to stay protected in the nucleus. Translation is the process that which the newly created mRNA is used to help organize and create an amino acid chain that will need for the protein being made. I usually tell my student to think about it as a doctor's note. First, it has to written (transcribed) and then translated for non-science people to understand it