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Tutor profile: Stefan L.

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Stefan L.
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Questions

Subject: Biophysics

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Question:

What is structure-based drug-design?

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Stefan L.
Answer:

Structure-based drug design is a process by which researchers model, build and test a new therapy based on the known structure of the target molecule, typically a protein. The known target structure allows researchers to construct a therapy specific to it, thus maximizing therapeutic benefit and minimizing side-effects.

Subject: Biomedical Science

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Question:

What is the pathophysiology of Type I Diabetes?

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Stefan L.
Answer:

Type I Diabetes results from an autoimmune reaction in which the patient's immune system is somehow triggered, perhaps by a preceding gut viral infection, to attack and kill the insulin-producing beta islets of the pancreas. This eliminates the body's ability to produce the insulin that allows cells to absorb glucose from the blood, thus leading to diseases associated with high blood glucose.

Subject: Biochemistry

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Question:

What is the metabolic function of the electron transport chain and how does it compare to glycolysis and the Kreb's cycle?

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Stefan L.
Answer:

The electron transport chain is a eukaryotic cellular energy-generating process located in the cell's mitochondrial membranes that generates large amounts of adenosine triphosphate (ATP, the cell's energy source) by shuttling high-energy electrons from catabolized glucose molecules through various transmembrane complexes, finally resulting in combination with molecular oxygen to form water as an end-product. It generates more ATP than glycolysis, in which glucose itself is catabolized into phosphorylated byproducts, and the Kreb's cycle that further degrades the pyruvate product of glycolysis.

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